Influence of altered coagulation and fibrinolysis status on disease activity of inflammatory bowel disease

Objectives To evaluate altered coagulation and fibrinolysis status,and to analysis factors associated with disease activity in active patients with inflammatory bowel disease.Methods A cohort of 271 consecutive patients with active IBD was compared with healthy controls for coagulation and fibrinolysis status.Analyses were done to elucidate the associations between altered coagulation and fibrinolysis status stratified by gender and inflammatory parameters.Results The mean levels of platelet,platelet distribution width,prothrombin time,fibrinogen,activated partial thromboplastin time were significantly higher in male or female patients with Crohn's disease(CD) or ulcerative colitis(UC) than that in controls(all P0.05),whereas mean platelet volume was lower(P0.01).Furthermore,linear regression indicated that fibrinogen was an independent predictor of ESR(β=1.316,P=0.000) and CRP(β=1.233,P=0.015) in male patients with active UC.And Crohn's Disease Activity Index was predicted by platelet(β=0.436,P=0.037) and prothrombin time(β=0.810,P=0.000) in female patients with CD.Conclusion It is suggested that in IBD patients,abnormalities in coagulation and fibrinolysis status were associated with disease activity.Fibrinogen,platelet and prothrombin time were predictors of inflammatory parameters.