Factors of carrier affecting the adhesion of microspheres via intranasal administration

Intranasal microspheres have gained increased interest in recent years.The mucoadhesive properties between microspheres and nasal mucosa via intranasal administration were remarkable affected by factors such as species of polymer materials,molecular weight,pH and modifications.During the process of the preperartion,the mucoadhesion of microspheres has a great relationship between the above facrors.Thus this review focuses on how the above factors affecting the mucoadhesion of microspheres via intranasal administration.