Meta-Analysis on Randomized Controlled Trials of Tongxinluo Capsules for Cerebrovascular Disorders

【Objective】To assess the efficacy and safety of Tongxinluo Capsules for cerebrovascular disorders by meta analysis.【Methods】Randomized controlled trials(RCT) of Tongxinluo Capsules for cerebrovascular disorders were got by searching China Journal Full-text Database(from 1996 to May,2006),China Best Doctoral and Master's Dissertations(from 1996 to May,2006),MEDLINE(from 1996 to May,2006),and Cochrane Library with computer,and were screened by manual search.RevMan 4.2 software and SAS were used in Meta-analysis.【Results】Thirty seven RCT were included,in which involved 2791 patients.Among them,1764 patients were treated with Tongxinluo Capsules,and other 1572 served as the controls. Meta-analysis results showed that the difference of the total efficacy in 31 RCT was significant(P0.01),and the difference of neurological deficit in 7 RCT of Tongxinluo Capsules for cerebral infarction was also significant(P0.05).Adverse reactions were scarcely found,and no obvious toxic and side effect was found.【Conclusion】The present evidence indicates that Tongxinluo Capsules exert a higher therapeutic effect rate for cerebrovascular disorders.However,to obtain more profound evidences,more high-quality,large-sized and double blind RCT are still required to prove the efficacy and the safety.