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2006•Chinese Journal of Clinical GastroenterologyRequires access

Study on the Inhibition Effect of Arsenic Trioxide on Human Gastric Carcinoma

Ming Cai

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Abstract

Objective To study the biological effects of arsenic trioxide(As_2O_3) on human gastric cancer cells MKN-28 in vitro.Methods By means of light microscope,MTT reduction assay and flow cytometry to observe apoptosis of human gastric cancer cells in different effect time and concentration of As_2O_3.Results As_2O_3 could significantly inhibit the proliferation of MKN-28 cells and the inhibitory effect was dose-and-timed ependent.The cells treated by As_2O_3 showed a typical apoptotic morphology and hypodiploid peak before G_1 phase.Conclusion As_2O_3 not only could inhibit significantly the proliferation of MKN-28 cells but also could induce apoptosis of MKN-28 cells.

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What this paper is about

Objective To study the biological effects of arsenic trioxide(As_2O_3) on human gastric cancer cells MKN-28 in vitro.Methods By means of light microscope,MTT reduction assay and flow cytometry to observe apoptosis of human gastric cancer cells in different effect time and concentration of As_2O_3.Results As_2O_3 could significantly inhibit the proliferation of MKN-28 cells and the inhibitory effect was dose-and-timed ependent.The cells treated by As_2O_3 showed a typical apoptotic morphology and hypodiploid peak before G_1 phase.Conclusion As_2O_3 not only could inhibit significantly the proliferation of MKN-28 cells but also could induce apoptosis of MKN-28 cells.

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Available abstract

Objective To study the biological effects of arsenic trioxide(As_2O_3) on human gastric cancer cells MKN-28 in vitro.Methods By means of light microscope,MTT reduction assay and flow cytometry to observe apoptosis of human gastric cancer cells in different effect time and concentration of As_2O_3.Results As_2O_3 could significantly inhibit the proliferation of MKN-28 cells and the inhibitory effect was dose-and-timed ependent.The cells treated by As_2O_3 showed a typical apoptotic morphology and hypodiploid peak before G_1 phase.Conclusion As_2O_3 not only could inhibit significantly the proliferation of MKN-28 cells but also could induce apoptosis of MKN-28 cells.

Key concepts: Arsenic trioxide, Apoptosis, Flow cytometry, Medicine, In vitro, Gastric carcinoma, MTT assay, Cancer cell

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