Application values of CRP,PCT,and IL- 6 in early diagnosis of sepsis among neonates with premature rupture of membrane

Objective: To explore the application values of C- reactive protein(CRP),procalcitonin(PCT),and interleukin-6(IL-6) in early diagnosis of sepsis among neonates of premature rupture of membrane(PROM). Methods: Fifty- eight neonates of PROM treated in the hospital from March 2012 to March 2013 were collected and divided into observation group(30 neonates with sepsis) and control group(28 normal neonates); the levels of CRP,PCT,and IL- 6 in venous blood specimens of the neonates were detected on the first day after birth,CRP and PCT levels were detected again at three days after birth. Results: IL- 6 level at birth in observation group was(100. 32 ± 38. 72) ng / L,which was statistically significantly higher than that in control group [(4. 56 ± 2. 19) ng / L]( P 0. 05); CRP level at birth in observation group was(8. 74 ± 3. 32) mg / L,which was statistically significantly higher than that in control group [(2. 35 ±1. 09) mg/L](P 0. 05). PCT levels at birth and at three days after birth in observation group were(7. 02 ±5. 23) μg/L and(10. 76 ±3. 27) μg/L,respectively,which were statistically significantly higher than those in control group [(1. 19 ± 8. 24) μg/L and(1. 21 ±1. 42) μg/L](P 0. 05). The critical values of CRP and PCT in diagnosis of neonatal infection at birth were 7. 2 mg/L and 1. 69μg / L,respectively,the sensitivities and specificities were 56%,60% and 77%,85%,respectively. At third days after birth,the critical values of CRP and PCT were 7. 6 mg / L and 1. 82 μg / L,respectively,the sensitivities and specificities were 60%,67% and 91%, 87%,respectively. The critical value,sensitivity,and specificity of IL- 6 at birth were 7. 8 ng / L,93%,and 96%,respectively. Conclusion: The sensitivity and specificity of IL- 6 in neonates with sepsis at birth are the highest,the sensitivity of PCT is slightly superior to CRP.