Clinical observation on the patients with hypertension treated with Dexmedetomidine in tracheal extubation after general anesthesia

Objective: To Observe the effect,safety and adverse reaction of Dexmedetomidine administrated to the hypertensives during tracheal extubation after general anesthesia.Methods: 80 patients with primary high blood pressure,Ⅰ～Ⅱstage,were divided into two groups stochastically(group Dexmedetomidine,i.e.group A and group control,i.e.group N).ASAⅡ～Ⅲ grade blood pressure was controlled below 160/90 mmHg.At the end of operation and before extubation,injection Dexmedetomidine 0.5 μg/kg with minipump was administered in group Dexmedetomidine,but in group control was intravenous injection of partes aequales physiological saline.RR,MAP,HR,SpO2,Ramsay conscious-sedation score,restlessness rate and bucking were observed and recorded before anesthesia,after administration,ahead of extubation,at the moment of extubation and after extubation 3 min,5 min and 10 min respectively.Results: Campared with before anesthesia,MAP of patients in group N rose obviously at the moment of extubation and after extubation 3 min and 5 min(P0.05),and HR and RR speeded up(P0.05),(2)BP,HR and RR in group A were steady,and there was significant difference in both groups(P0.05),(3) Compared with those in group N,there was difference of MAP and HR at the moment of extubation and after extubation in group A(P0.05).As for the timescale of extubation,there was no significant difference between both groups(P0.05),(4) The rate of restlessness in group A was below(P 0.05).In 2 cases,respiration decreased lightly,O2 descended temporarily,and recovered with oxygen face mask.Conclusion: The injection of Dexmedetomidine 0.5 μg/kg with minipump can suppress extubation stress and relieve restlessness due to general anaesthesia,domestic-made Dexmedetomidine can be applied to extubation on hypertensives safely.