2006•Xinxiang yixueyuan xuebaoRequires access
The study on the expression of immediate-early response gene c-fos,c-myc,c-jun,in VSMC after autogenous vein grafts
Yongjun Wang
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Abstract
Objective To investigate the changes of immediate-early response gene(c-fos,c-myc,cjun) in vascular smooth muscle cells(VSMC) after autogenous vein grafts.Methods Autogenous transplanting vein models for 60 rats were developed.The changes of vascular VSMC proliferation and immediate-early response gene were detected by using immunohistochemistry technique.Results Expression of c-fos,c-jun,c-myc was observed at 2 h after the grafting.Expression of c-fos,c-jun peaked at 6 h after the grafting and c-myc at 1 week.Conclusion Expression status of c-fos,c-myc,c-jun is closely related to VSMC proliferation and regulates for it,particularly in the initial stage.