Effects of trimetazidine on plasma levels of homocysteine,matrix metalloproteinase-9 and vascular endothelial function in elderly patients with unstable angina

Objective To investigate the levels of plasma homocysteine(Hcy) levels,matrix metalloproteinase-9(MMP-9) and the endothelial function after use the trimetazidine hydrochloride in treatment of elderly patients with unstable angina pectoris(UA).Methods Totally 150 cases with UN patients(age≥60 years) were random!) divided into control group(75 cases) and observation group(75 cases) by random number table,2 groups received nitrates,aspirin,statins,beta blockers and other conventional,the observation group added trinietazidine hydrochloride(20 mg,3 times/d),2 groups received I month of treatment,levelof plasma Hcy,MMP-9 and endothelial cells function before and alter treatment were tested.Results There were no significant difference of Hcy.MMP-9 and endothelial function between the 2 groups before treatment(P 0.05);after 1 month treatment,2 groups' Hcy,MMP-9,endolhelin-1(ET-1) and von Willehrand factor(vWF)were significantly decreased(P 0.05).nitric oxide(NO) and brachial artery flow mediated endothelial dependent dilatation rate(FMD) were significantly increased(P 0.05).The observation group was better than the control group(P 0.05).Conclusion Trimetazidine hydrochloride can improve endothelial function by reducing Hcy,FT-1 and vWF levels,and increasing NO levels,and reduced MMP-9 level to prevenl of myocardial remodeling.