Assessments of modality and function right ventricular in patients with arial septal defect by single cardiac cycle real-time three dimensional echocardiography

Objective To investigate the shape and function of right ventricle in patients with arial septal defect.Methods Thirty-three healthy volunteers and 18 ASD patients were enrolled consecutively as normal controls and the ASD group respectively.All the participants received routine echocardiography.Single cardiac cycle real-time three dimensional echocardiography(sRt-3DE)were performed in all to evaluate parameters concerning modality and systolic function of participants' right ventricle.All the parameters were indexed by body surface area(BSA).Further correlative analysis was calculated between right ventricular parameters and right heart pressure by cardiac catheter as well as right ventricular parameters and BSA indexed maximum diameter of ASD.Results Indexed right ventricular end diastolic volume(IEDV_RV)and end systolic volume(IESV_RV),indexed right ventricular systolic volume(ISV_RV)and right ventricular ejection fraction(RVEF)were greater in the ASD group than in controls(P0.001,P0.01,P0.001,P0.05).IEDV_RV,IESV_RV and ISV_RV had positive relation with pulmonary pressure measured by cardiac catheter(r=0.61,r=0.79,r=0.83,all P0.01)and IASD(r=0.57,P0.05;r=0.6,P0.01;r=0.55,P0.05 respectively)while they had negative relation with LVEF(r=-0.47,r=-0.5,r=-0.52;all P0.05).Conclusions Left-to-right shunt in ASD patients may lead to an aggressive increase of pulmonary pressure and right ventricular volume.The enlargement of right ventricle increases right ventricular contraction.Meanwhile,it affects the modality and function of left ventricle.