Research on the synthesis of 4-hydroxy-3-isobutylphenylboronic acid

The route was started with 5-bromo-2-hydroxybenzaldehyde(2),which was converted into the corresponding(4) by benzylation,followed by the reaction with Wittig reagent.4-Benzyloxy-3-isobutenylphenylboronic acid(5)as synthesized by a three-step reaction of Grignard reaction and esterification and hydrolysis from(4).The title compound(1) in overall yield of 63% was synthesized by the hydrogenation reduction reaction of(5),and the structures of related intermediates and the product were characterized by 1H NMR,13C NMR and MS spectra.