Value of the Joint Detection of PSA and ALP in the Early Diagnosis of Prostate Cancer Bone Metastasis

Objective: To investigate the role and significance of the joint detection of prostatic specific antigen(PSA) and alkaline phosphatase(ALP) in the early diagnosis of prostate cancer bone metastasis.Methods: By radionuclide bone imaging,98 cases of prostate cancer were divided into bone metastasis group and non-metastasis group.Serum levels of PSA and the ALP were detected in all patients,and the results were analyzed and compared statistically between the two groups in relation to metastasis status.Radionuclide bone scintigraphy were adopted to find radioactive foci.Results: The serum PSA and ALP levels were higher in bone metastasis group than in non-metastasis group(P0.05),and both indices were positively correlated with the severity of bone metastasis.ALP positive rate was significantly different between the two groups(P0.05) while PSA positive rate had no difference(P0.05).The sensitivity(specificity) of joint detection were significantly different from that of ALP or PSA alone.The radionuclide bone scintigraphy positive rate was 58.2%,and abnormal radioactive dense foci were located in the thoracic and lumbar parts.Conclusion: PAS and ALP joint detection is useful for the early diagnosis of prostate cancer bone metastases,and can improve the diagnostic rate.