Changes in pepsinogen, gastrin and helicobacter pylori(Hp) antibody level before and after Hpylori eradication in patients with pepticulcer

Objective To study the possible changes in pepsinogen,gastrin and H.pylori antibody level before and after H.pylori eradicationin patients with peptic ulcer.Methods Patients were randomized to receive omeprazole,roxithromycin and sucralfate suspension for 2 weeks andomeprazole for 2 weeks(38 patients) or omeprazole for4 weeks(20 patients,control group).H.pylori,pepsinogen,gastrin and H.pylori antibodylevels were measured before and after treatment.Four weeks after the completion of treatment,gastric ulcer(GU) and duodenal ulcer(DU) andH.pylori status were examined.Results Of 13 GUpatients in treatment group,the ulcers were healed in 10 patients(76.92%),of 25 DU pa-tients in treatment group,the ulcers were healed in 18 patients(72%),which were significantly higher than those of control group.Hp-IgG(+)patients decreased from34 patients(89.47 %.) before treatment to 15 patients(39.47%)after treatment.PG and GAS levels were significantlyhigher in H.pyloriPositive group,after treatment they decreased significantly(P0.05 andP0.01,respectively).Conclusion H.pylori pos-itive peptic ulcer can be effectively treated with omeprazole,roxithromycin and sucralfate suspension.The increase in pepsinogen and gastrin is as-sociated with H.pylori.Ggastrin increase has an important effect on pathogesis of Du and GU.