Hepatopancreatobiliary Complications among Patients with Inflammatory Bowel Disease

Objective To investigate the frequency and characteristics of hepatopancreatobiliary(HPB) complications among patients with Crohn`s disease(CD) and ulcerative colitis(UC).Methods A total of 606 inflammatory bowel disease(IBD) patients(68 CD,538 UC) treated by our hospital between 1990 and 2010 and 606 healthy subjects matched for age,sex,and body mass index(BMI) were enrolled.Frequency of HPB complications including gallstone disease(GD),nonalcoholic fatty liver disease(NAFLD),primary biliary cirrhosis(PBC),primary sclerosing cholangitis(PSC),autoimmune hepatitis(AIH),and chronic pancreatitis(CP) were compared between the IBD group and the control group.OR,95% confidence intervals(95%CI),and P values were calculated.P0.05 was considered statistically significant.Results The frequency of gallstone disease was 51.47%(35/68) among CD patients[OR=10.96,95%CI(4.181,28.724)] and 34.01%(183/538) among UC patients[OR=5.79,95%CI(4.053,8.264)],significantly different from that among the control group(P0.01).The frequency of NAFLD was 64.71%(44/68) among CD patients[OR=8.56,95%CI(3.854,18.994)] and 69.33%(373/538) among UC patients[OR=8.41,95%CI(6.378,11.084)],significantly different from that in the control group(P0.01).Screening for IBD in Patients with uncommon HPB diseases showed that the frequency of PBC,PSC,AIH,and CP were 2.25%(7/311),4.49%(4/89),3.33%(2/60),and 0.93%(2/213),respectively.Conclusion GD and NAFLD are among the most common extraintestinal manifestations of IBD,especially in patients with CD or UC.We suggest that the diseased of IBD and HPB be reciprocally screened under a normalized system.