Pharmacodynamics effect of enrofloxacin on four aquatic pathogenic vibrio

The minimal inhibitory concentration(MIC) and the minimum bactericidal concentration(MBC) of enrofloxacin against 12 strains of Vibrio alginolyticus,V.mimicus,V.harveyi,V.vulnificus were determined by two-fold broth macrodilution method and the results showed that the MIC and MBC were 0.1?0.8 mg/L and 0.4?3.2 mg/L respectively.On the basis of these,4 sensitive strains of 12 vibrio srtains were measured with the killing-curves and the PAE in different concentrations of enrofloxacin.The results showed that every concentration of enrofloxacin against V.alginolyticus X040625-R had a strong anti-bactericidal effect,but that against V.harveyi M071202-H,V.vulnificus Q050723-C,V.mimicus H010911-Z showed that the three bacteria was inhibited in the lower concentration and gradually killed with the increasing concentration.The PAE of enrofloxacin had a direct relationship with the concen-tration and the mixing time of the drug.The PAE of enrofloxacin against V.alginolyticus X040625-R was the longest while that against V.harveyi M071202-H was the shortest.