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THE SYNTHESIS OF LIQUIRITIGENIN AND ISOLIQUIRITIGENIN

Lanxiang Yang

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Abstract

Licorice is used as an importan t traditional herbal medicine. The flavonoids inlicorice is one kind-of components having higher biological effects ,among them ’liquiritigenin(VI)and isoliquiritigenin ( Ⅳ )have special activities in the treatment of AIDS.In this article l differentways to synthesize the two compounds ,including synthesis of isoliquiritigenin(Ⅳ)by Fries-reaction,Aldol condensation under acid or base catalyst l and conversion to liquiritigenin(Ⅵ )fromisoliquiritigenin(Ⅳ)were studied and a better procedure was obtained.

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Licorice is used as an importan t traditional herbal medicine. The flavonoids inlicorice is one kind-of components having higher biological effects ,among them ’liquiritigenin(VI)and isoliquiritigenin ( Ⅳ )have special activities in the treatment of AIDS.In this article l differentways to synthesize the two compounds ,including synthesis of isoliquiritigenin(Ⅳ)by Fries-reaction,Aldol condensation under acid or base catalyst l and conversion to liquiritigenin(Ⅵ )fromisoliquiritigenin(Ⅳ)were studied and a better procedure was obtained.

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Available abstract

Licorice is used as an importan t traditional herbal medicine. The flavonoids inlicorice is one kind-of components having higher biological effects ,among them ’liquiritigenin(VI)and isoliquiritigenin ( Ⅳ )have special activities in the treatment of AIDS.In this article l differentways to synthesize the two compounds ,including synthesis of isoliquiritigenin(Ⅳ)by Fries-reaction,Aldol condensation under acid or base catalyst l and conversion to liquiritigenin(Ⅵ )fromisoliquiritigenin(Ⅳ)were studied and a better procedure was obtained.

Key concepts: Liquiritigenin, Isoliquiritigenin, Chemistry, Traditionalism, Traditional medicine, Organic chemistry, Medicine, Philosophy

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