Application of combined use of continuous glucose monitoring system and continuous subcutaneous insulin infusion pump in critical patients with type 2 diabetic mellitus in ICU

Objective To investigate the therapeutic outcomes of continuous glucose monitoring system(CGMS) and continuous subcutaneous insulin infusion pump system(CSII) in type 2 diabetes mellitus(T2DM) patients with critical condition in intensive care unit(ICU).Methods A total of 120 T2DM patients in ICU was randomly divided into three groups with 40 cases each.CGMS combined with CSII was used in group A,CSII alone in group B and repeated injection of insulin therapy in group C.The capillary blood glucose of finger tip was monitored in groups of B and C.The changes of fasting blood glucose(FBG), mean amplitude of glycemic excursions(MAGE) and the number of hypoglycemia events were recorded and compared among three groups after for treatment 7 days.Results After pump therapy for 7 days, the whole day glucose, MBG and MAGE were all significantly lower in groups of A and B than those before treatment(P0.05),which were lower in group A than those in group B(P0.05).The mean blood glucose(MBG), mean amplitude of glucose fluctuation(MAGF) and hypoglycemia events of group A were obviously less than those in group B(P0.05). Conclusion CGMS can depict a continuous blood glucose curve,discover hyperglycemia or hypoglycemia events. CGMS combined with CSII is more beneficial to the glucose control in the critical T2DM patients in ICU.