Relationship between duodenogastric reflux and pathology of gastric mucosa

[Objective] To investigate the relationship between duodenogastric reflux (DGR) and pathology of gastric mucosa in the patients with primary bile reflux gastritis.[Methods] Endoscopy and histologic examination analysis were performed in 218 patients with primary bile reflux gastritis.[Results] The patients were divided into three groups,group Ⅰ (the low bile reflux group,61 patients),group Ⅱ (the moderate bile reflux group,91 patients) and group Ⅲ (the high bile reflux group,64 patients),based on the severity of bile reflux indicated by gastroscopy.The frequency of helicobacter pylori (H.pylori) infection and topographic abnormalities of the antral mucosal detected by gastroscopy for hyperemia,hemorrhagic spots or macula,erosion,and penetrating blood vessel,respectively,were not statistically significantly different in different bile reflux groups (P 0.05).The scores of chronic inflammation and active inflammation were higher in patients with H.pylori infection than that in patients without H.pylori infection (1.76±0.77) vs.(1.16±0.79),(1.72±0.66) vs.(1.06±0.59),P 0.05).There was a tendency that the frequency of the antral intestinal metaplasia or antral atrophy increase with the severity bile reflux (P 0.05).[Conclusion] Excessive bile reflux is related to chronic lesion of gastric mucosa,regardless of H.pylori infection.Although the topographic abnormalities of the antral mucosal detected by gastroscopy were not different,biopsy was very important for the tendency that the frequency of the antral intestinal metaplasia or antral atrophy increase with the severity bile reflux.