2006•The Journal of Spinal SurgeryRequires access
Expression of vascular endothelial growth factor in spinal cord continuous compression injury
Wen Xue
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Abstract
ObjectiveTo investigate the expression changes and effects of vascular endothelial growth factor(VEGF) in rats' spinal cord continuous compression injury.MethodsThe model with spinal cord continuous compression injury was made by compressing the posterior of spinal cord with a blunt plastic screw.Sixty Wistar male rats were randomly divided into compression group and control group.Changes of the behavior and hind-limb function of experimental rats were observed.The expression changes of vascular endothelial growth factor at various times were detected at the level of mRNA and protein by hybridization in situ and immunohistochemistry. ResultsThe hind-limb function of experimental rats weakened significantly,further deteriorated after 2 days,and recovered slightly following the time going on and obviously after 3 weeks.VEGF expressed more significantly at the level of mRNA and protein in injured spinal cord of experimental group than in the spinal cord of control group(P0.05),peaked after 2 days,decreased significantly after 1 week(P0.05),and disappeared after 3 weeks.ConclusionVEGF expression might play a role in hypoxia tolerance and repair for spinal cord continuous compression injury.