Synthesis and Molluscicidal Activity of Phoxim Analogues

In order to search for novel more effective and less toxic molluscicides,nine new phoxim analogues(2a-2i) were synthesized from substituted phenylacetonitriles by oximation and thiophosphorylation. All compounds were confirmed by elemental analyses,IR,1HNMR and MS. Preliminary biological screening showed that compounds 2a,2b and 2h appeared to have significant molluscicidal activity against Oncomelanis hwpensis snails. The LC50 of the compounds 2a,2b and 2h against snails were 0.31,0.33 and 0.38 mg/L,respectively.