Analyses of the Effects of BDNF on Memory Ability in Dementia Senile Mice's GrayIof CA1 Area

Objective To explore the mechanism of the BDNF on senile dementia mice.Method The senile dementia mice were tested by Morris water maze.The changes of the hippocampus synaptic structural parameters and Gray typeⅠwere studied with transmission electron microscope and morph metric analysis.Result The spontaneous activity and exploratory behavior in the new and abnormal environment were obviously increased.The step-through latency(STL) was prolonged significantly after electrical stimulation.After treatment by BDNF the volume density on area of Gray type Ⅰ synapses in CA1 sector of hippocampus were increased significantly,the parameters were decreased compared with the normal mice.Especially,the curvature of synaptic interface,the width of synaptic cleft and the thickness of postsynaptic density were increased compared with the control group,while the parameters were decreased compared with the normal mice.Conclusion The change of the synaptic structure and decrease in the synaptic number is one of the reasons on dementia pathological mechanism.BDNF can promote synaptic reconstruction and improve the memory of senile dementia mice.