Comparative Research of Intravitreal Bevacizumab Versus Triamcinolone Treatment for Macular Edema in Retinal Vein Occlusion

Objective: To compare the efficiency of intravitreal injection of bevacizumab or triamcinolone for the treatment of macular edema in retinal vein occlusion.Methods: A total of 48 eyes with macular edema second to retinal vein occlusion were included.All cases were diagnosed by the examinations of regular inspection,fundus fluorescein angiography(FFA) and optic coherence tomography(OCT),with vision≤0.6 and central macular thickness(CMT) ≥250 μm.Both groups received intravitreal injection of either 1.25 mg/0.05 ml of bevacizumab(Be group,n=16) or 4 mg/0.1 ml of triamcinolone(TA group,n=32).Best corrected visual acuity(BCVA) were compared between the two groups at baseline and in 1,2,3 days and 1,2,4,8,12,24 weeks after treatment,meanwhile,CMT,CMV,and AVG were also compared at baseline and in 1,2,4,8,12,24 weeks.Results: BCVA of Be group were significantly increased from the first day(P0.01),and reached to the peak in 8 weeks(BCVA=0.618 8±0.207 3).There were 11 cases' BVCA(68.75%) were increased more than three lines in one week.BCVA of TA group were significantly increased in each time point too(P=0.000),BCVA in 4(BCVA=0.431 9±0.198 9),8(BCVA=0.539 1±0.217 7),12(BCVA=0.520 3±0.212 5) weeks,were similar,but slowly decreased in 24 weeks(BCVA=0.360 9±0.184 8).There were 15 cases' BVCA(41.67%) were increased more than 3 lines in one week.CMT of Be group was significantly decreased in 1,2,4,8,12,and 24 weeks(P0.05),and dropped to the bottom in 8 weeks(CMT=245.437 5±46.740 3 μm).CMT of TA group were significantly increased in each time point(P=0.000).Compared with baseline,the changes of CMV and AVG in both groups were significant.BCVA had negative correlation with CMT,CMV,and AVG,respectively.High IOP were seen only in TA group.Conclusion: Intravitreal injection of bevacizumab or triamcinolone for the treatment of macular edema in retinal vein occlusion could increase BCVA and reduce macular edema instinctively,but the difference was not significant.BCVA has negative correlation with CMT,CMV,and AVG respectively.CMV and AVG also can reveal the effect of treatment,but are less sensitive than CMT.