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1998•Chinese Journal of New Drugs and Clinical RemediesRequires access

Buspirone vs diazepam in treating anxiety disorders in a double_blind study

Chen Zuo

Open publisher page 4 citations

Abstract

AIM: To compare the effects and adverse reactions of buspirone and diazepam in treating anxiety disorders. METHODS: Forty_five anxious patients were divided randomly into 2 groups: 23 patients (M 11, F 12, age 38±s 13 a) were treated with buspirone, 15 mg, po, tid for 4 wk; 22 patients (M 9, F 13, age 41±11 a) were treated with diazepam, 7.5 mg, po, tid for 4 wk. RESULTS: The total clinical effective rates were 87% for buspirone, and 90% for diazepam (P0.05). The adverse reactions in diazepam group was higher than in buspirone group. But this did not hinder the treatment because the adverse reactions were mild. CONCLUSION: Buspirone showed the same effects but less adverse reactions than diazepam.

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AIM: To compare the effects and adverse reactions of buspirone and diazepam in treating anxiety disorders. METHODS: Forty_five anxious patients were divided randomly into 2 groups: 23 patients (M 11, F 12, age 38±s 13 a) were treated with buspirone, 15 mg, po, tid for 4 wk; 22 patients (M 9, F 13, age 41±11 a) were treated with diazepam, 7.5 mg, po, tid for 4 wk. RESULTS: The total clinical effective rates were 87% for buspirone, and 90% for diazepam (P0.05). The adverse reactions in diazepam group was higher than in buspirone group. But this did not hinder the treatment because the adverse reactions were mild. CONCLUSION: Buspirone showed the same effects but less adverse reactions than diazepam.

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Available abstract

AIM: To compare the effects and adverse reactions of buspirone and diazepam in treating anxiety disorders. METHODS: Forty_five anxious patients were divided randomly into 2 groups: 23 patients (M 11, F 12, age 38±s 13 a) were treated with buspirone, 15 mg, po, tid for 4 wk; 22 patients (M 9, F 13, age 41±11 a) were treated with diazepam, 7.5 mg, po, tid for 4 wk. RESULTS: The total clinical effective rates were 87% for buspirone, and 90% for diazepam (P0.05). The adverse reactions in diazepam group was higher than in buspirone group. But this did not hinder the treatment because the adverse reactions were mild. CONCLUSION: Buspirone showed the same effects but less adverse reactions than diazepam.

Key concepts: Buspirone, Diazepam, Adverse effect, Anxiety, Medicine, Anesthesia, Anxiolytic, Pharmacology

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