Effect of potassium channel opener pinacidil on ovarian cancer cell apoptosis

Aim To study the effect of potassium channel opener pinacidil on proliferation and apoptosis of ovarian cancer cell line SKOV3.Methods SKOV3 cells were treated with pinacidil(10,50,200,500 mmol·L-1 respectively).The effect of pinacidil on prolifieration of SKOV3 cells was assessed by MTT assay.The Hoechest33258 fluoresence staining was adopted for the apoptosis detection.Cell apoptosis also was detected by flow cytometry.Results Pinacidil inhibited the proliferation of SKOV3 cells in dose-dependent manners,and induced cell apoptosis.Conclusions Potassium channel plays an important role in regulating proliferation of SKOV3 cells,and potassium channel opener can induce cell apoptosis.