Effect of Metformin and Rosiglitazone Treatment on Polycystic Ovary Syndrome

Objective: To study the clinical effects of metformin and rosiglitazone treatment in women with Polycystic Ovary Syndrome(PCOS).Methods: 55 women with PCOS were randomized in to two groups and treated for 12 weeks.Metformin group had 30 patients and rosiglitazone group had 25.Several biomedical parameters were recorded before and after the treatment,including weight,plasma level of glucose,sexual hormones and insulin.Menstruation changes and drug adverse reactions were also observed.Results:①Metformin can significantly decrease body weight(P0.05),while rosiglitazone had no evident effect.②Both drugs can significantly decrease the basal insulin level,INSAUC level and insulin resistance level(HOMA IR),rosiglitazone group decreased more(P0.05).③Both drugs can significantly decrease the luteinizing,androstenedione and testosterone levels.④Ovulation rate in both groups increased but had no difference.⑤Metformin's adverse reactions were diarrhea and nausea;rosiglitazone's were weight gaining and edema.Conclusions:Rosiglitazone and metformin can effectively improve insulin resistance of PCOS.Metformin is cheap and can decrease the body weight;rosiglitazone has better therapeutic effect on insulin resistance and hyperinsulinemia.