Clinical Study of Three Different Modes of Blood Purification for Clearance of Serum Phosphate in Maintenance Hemodialysis Patients

Objective To study the effect of three different modes of blood purification(HD: hemodialysis,HDF: hemodiafiltration,and HD+HP: hemodialysis and hemoperfusion) for clearance of serum phosphate in maintenance hemodialysis patients.Methods Fourty-eight patients with hyperphosphatemia undergoing maintenance hemodialysis in our department between February 2009 and February 2011 were recruited in our study.They were divided into three groups: HD group,HDF group,and HD+HP group with 16 patients in each.Serum levels of calcium,phosphate,intact parathyroid hormone(iPTH) and calcium-phosphate product were measured and analyzed before and four,eight weeks after the therapy.Results Four and eight weeks after the therapy,concentrations of Ca,Pi,iPTH and Ca×Pi in HD group did not obviously change(P0.05),but levels of Pi,iPTH and Ca×Pi in HDF group and HD+HP group significantly decreased compared with those before therapy(P0.05,P0.01),except for Ca(P0.05).At the same time,difference was not detected between HDF and HD+HP groups(P0.05).Conclusion HDF and HP can effectively eliminate serum phosphate in maintenance hemodialysis patients,but HD has poor effect.