2011•Journal of Nongken MedicineRequires access

Relaxant effects of Coreopsis extracts on rat thoracic aortic and underlying mechanisms

HA Mu-la

Abstract

Objective:To investigate the relaxant effects and mechanisms of Coreopsis extracts on isolated thoracic aorta of rat. Methods:Study was performed with the model of isolate rat thoracic aorta rings in organ bath.and the contractile changes were recorded. Results:Coreopsis extracts obviously relaxed rat aortic rings pre-contracted by PE or KCl with endothelium intact or denuded in a dose dependent manner.Cumulative application of Ca2+ induced a concentration-dependent contraction in rat aortic rings without endothelium in Ca2+ free K-H solution pre-depolarized with KCl;Both Ca2+ and PE-induced contraction were dramatically attenuated after pretreated with Coreopsis extracts(3.00 g·L-1) for 10min in Krebs solution without Ca2+. Conclusion:The relaxant effect of Coreopsis extracts on rat thoracic aorta rings were endothelium-independent.Coreopsis extracts inhibited Ca2+-induced contraction by reducing Ca2+ influx and intracellular Ca2+ release.

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Key concepts: Contraction (grammar), Thoracic aorta, Chemistry, Endothelium, Aorta, Intracellular, Pharmacology, Dose dependence