Therapeutic effects of eradicating Helicobacter pylori on gastric hyperplastic polyps

Objective To study the therapeutic effects of eradicating Helicobacter pylori(H pylori) on the gastric hyperplastic polyps.Methods Fifty-six patients with H.pylori infection and gastric hyperplastic polyps(3～10 mm in diameter) were randomly assigned to a treatment group(n=28) receiving a quadruple therapy of proton-pump inhibitor(omeprazole or lansoprazole),clarithromycin,bismuth citrate and tinidazole,or to a control group(n=28) which receiving proton-pump inhibitor(omeprazole or lansoprazole).Patients underwent endoscopy and H.pylori examination regularly before enrollment and 4 to 12 months after the end of treadment.Results Twenty-six patients in the treatment group and 22 in controls completed the entire trial in the entire study,H.pylori was eradicated in 23 of 26 patients(88.5%) and the polys had disappeared in 14 of a11 23 patients(60.9%) during 4 to 12 months follow-up period,after the end of treatment.However,no change was seen in the polyps and H.pylori status in the controls during same period(P0.05).Conclusions Most of gastric hyperplastic polyps disappeared after the eradication of H.pylori.Thus,before endoscopic removal of polys in patients with H.pylori infection,the eradication of H.pylori might be tried.