Clinical Analysis of Abnormal Thyroid Hormone in Systemic Lupus Erythematosus and Their Relationship

Objective To evaluate the concentration of thyroid hormone in systemic lupus erythematosus(SLE) patients and the association with the disease activity.Methods The serum concentration of thyroid hormone(FT3,FT4,TSH) in 86 SLE patients(47 in active phase,39 in stable phase) and 68 healthy controls were measured.Results SLE patients had a significantly higher prevalence of thyroid dysfunction(44.2%) than the control group(8.8%)(P0.05).Significantly lower FT3,FT4 levels were detected in SLE patients in active phase than control group and SLE patients in stable phase(P0.05).While no significant difference was found in the serum concentrations of FT3,FT4 between stable SLE patients and the healthy controls.(P0.05).The level of systemic lupus erythematosus disease activity index(SLEDAI)and Systemic Lupus International Collaborative Clinics/American College of Rheumatology Damage Index(SLICC/ACRDI) in thyroid hormone abnormal group was significant higher than the normal group(P0.05).Conclusion The abnormal of thyroid hormone could be seen in the SLE patients.The decreasing of thyroid hormone has a close relationship with the disease activity and organ damage in SLE patients,and it is valuable in evaluating and treating the SLE patients.