Effect of β-elemene on the proliferation and cell cycle of hepatic carcinoma cell

Objective To study the effect of β-elemene on the proliferation and cell cycle of hepatic carcinoma cells.Methods Hepatic carcinoma 7402 cells were cultured in vitro,and treated with β-elemene for 48 h;MTT assay was used to evaluate the proliferation of 7402 cells;Cell cycle was analyzed by using flow cytometry with PI staining.Results After treated with β-elemene,the proliferation of 7402 cells was apparently inhibited in a dose-dependent manner;FCM assays showed that cells in S and G2 phases were decreased,while increased in G1 phase,which indicated that G1 phase arrest happened.Conclusion β-elemene can directly influence the proliferation and cell cycle of hepatic carcinoma cells,arrest cells entering S phase from G1 phase.