Significance of serum neuron-specific enolase in the early evaluation of brain damage of late preterm with perinatal asphyxia

Objective To investigate the value of serum neuron-specific enolase(NSE)levels in the diagnosis of neonatal asphyxia Methods 154 late-preterm neonates were enrolled in the study,including 94 with neonatal asphyxia for experimental group,52 with perinatal asphyxia,42 without brain damage and 60 normal ones for control group.For all the research objects blood samples were obtained for NSE detecting and Apgar scores were evaluated on proper time.MRI was performed 3~7 days after birth in experimental group. Results The levels of serum NSE in 52 with perinatal asphyxia were significantly higher than those in ones without brain damage and in control group.There were no significant difference between the levels in ones without brain damage and in control group.Conclusion Serum NSE level can be used as the early objective markers for evaluating the prognosis of brain damage due to late preterm perinatal asphyxia.