Study of non-pharmaceutical treatment intervention in patients with hyperlipidemia

Objective To observe the regulatory effect of non-pharmaceutical treatment on lipid profile in patients with dyslipidemia.Methods Ambulatory patients with dyslipidemia who had not received any treatment,were intervened with non-pharmaceutical treatment for six weeks,including instructions about diet control,life style improvement and health education and others.The changes in serum total cholesterol(TC),triglycerides, low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C) and body mass index were measured pre-and post-intervention.Results After six weeks of non-pharmaceutical treatment in 45 patients with dyslipidemia,serum TC decreased from((7.05)±(0.97)) mmol/L to((5.57)±(1.40)) mmol/L,in average decreased by 21%(P(0.01)),LDLC decreased from((4.28)±(0.75)) mmol/L to((3.64)±(1.31)) mmol/L,in average decreased by 15%(P(0.01)),HDL-C increased from((1.39)±(0.28)) mmol/L to((1.54)±(0.30)) mmol/L,in average increased by 11%(P(0.01));total rate of target attainment of LDL-C was(66.7)%,among which the patients with simple hyperlipidemia had a rate of target attainment(76.9)%,and the patients complicated with hypertension and/or diabetes had a rate of target attainment(52.6)%.Conclusion Non-pharmaceutical treatment can significantly decrease TC and LDL-C levels and increase the level of HDL-C,and should be the first-line treatment method and the basis of pharmaceutical treatment in patients with hyperlipidemia.