Clinical research on chronic severe hepatitis and liver cirrhosis patients with spontaneous bacterial peritonitis

OBJECTIVE To investigate the clinical features of chronic severe hepatitis and liver cirrhosis patients with spontaneous bacterial peritonitis(SBP).METHODS The clinical data of 59 chronic severe hepatitis and cirrhosis in patients with SBP from Jan 1st 2009 to Jun 30th 2011 and 54 patients with non-clinical SBP at the same period were statistically analyzed.RESULTS The ascites examination showed that the patients with the ratio of ascites polymorphonuclear leukocyte more than 0.50 accounted for 83.5% in the SBP group,while the patients with the ratio of of ascites polymorphonuclear leukocyte more than 0.50 accounted for 12.96% in the non-SBP group,the difference was statistically significant(χ2=9.87,P0.01);the cure rate of the SBP group was 37.29% after treatment with drugs.CONCLUSION SBP is a serious complication of advanced liver disease,ascites PMN ratio is a reliable indicator for the diagnosis of SBP;the best drug for treatment is the third-generation cephalosporins.