Clinical observation of dexmedetomidine administered with a micro infusion pump on endotracheal intubation during general anesthesia induction

Objective:To study the feasibility of dexmedetomidine administered with a micro infusion pump on endotracheal intubation and effect of dexmedetomidine administered with a micro infusion pump on hemodynamics change during general anesthesia induction.To determine the best dose of dexmedetomidine during general anesthesia induction.Methods:60 patients(ASAⅠ～Ⅱ),who needed laparoscopic surgery,were randomly divided into three groups(n=20).0.5,1.0,1.5 μg/kg dexmedetomidine was respectively injected with a micro infusion pump in theⅠ,Ⅱ,Ⅲ group,infusion time was 10 minutes.1.5 mg/kg propofol,4 μg/kg fentanyl and 0.15 mg/kg atracurium were injected intravenously after dexmedetomidine was injected 5 minutes.Endotracheal intubation was placed after dexmedetomidine was injected 10 minutes.Mean arterial pressure(MAP) and heart rate(HR) were measured before induction(T0),before intubation(T1),instant time after intubation(T2) and 1 minute(T3),5 minutes(T4) after intubation.Results:There was no significant difference in HR and MAP at T0 in the three groups(P0.05).HR at T1 significantly decreased than that at T0 in theⅠ,Ⅱ and Ⅲ groups(P0.05) and the decrease of HR in the Ⅲ group was most significant(P0.01).HR at T1 in the Ⅲ group significantly decreased than that in the Ⅰ and Ⅱ groups(P0.05).MAP at T1 did not change in the Ⅰ and Ⅱ groups(P0.05).MAP at T1 significantly decreased than that at T0 in the Ⅲ group(P0.05),and MAP at T1 in the Ⅲ group significantly decreased than that in the Ⅰ and Ⅱ groups(P0.05).HR and MAP at T2 significantly increased compared with at T1 in the Ⅰ group(P0.05),and HR and MAP at T2 in the Ⅰ group significantly increased than that in the Ⅱ group(P0.05).There was no significant difference in MAP and HR at T2 than that at T1 in theⅡ and Ⅲ groups(P0.05).HR and MAP at T3 significantly increased compared with that at T1 in the Ⅰ group(P0.05),and there was no significant difference in HR and MAP at T3 compared with that at T1 in the Ⅱ and Ⅲ groups(P0.05).There was no significant difference in HR and MAP at T4 compared with that at T0 in the Ⅱ and Ⅲ groups(P0.05).Conclusion:Anesthesia induction by dexmedetomidine administered with a micro infusion pump can be safely used in clinical,and hemodynamics is the most stable when 1.0 μg/kg dexmedetomidine is administered with a micro infusion pump in phase of induction and intubation in the three groups.1.0 μg/kg dexmedetomidine can be recommended as the best dose for clinical use.