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2004•Journal of Sichuan UniversityRequires access

Preparation and Bio-Distribution of 188Re-TTHMP

Guoping Liu

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Abstract

TTHMP (triethylenetetraaminehexamethylenephosphonic acid) was synthesized and labeled with 188Re. Also, the stability in vitro and bio-distribution in normal mice of 188Re-TTHMP were investigated. The labelling efficiency of 188Re was more than 95% on the conditions of SnCl2 of more than 0.5mg, TTHMP of more than 25 mg and at the pH value 1.5 to 3.5.188Re-TTHMP was stable in vitro with radiochemical purity of more than 92% in 4d. Bio-distribution experiment indicated that 188Re-TTHMP was principally incepted by bone of mice and the radioactivity got its peak value, (19.81±3.83)×10-2g-1, at 1 h post-injection.However, the retention of 188Re-TTHMP at bone was un-satisfied in that the bone uptake reduced to (6.23±1.52)×10-2g-1 at 48 h post-injection.

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What this paper is about

TTHMP (triethylenetetraaminehexamethylenephosphonic acid) was synthesized and labeled with 188Re. Also, the stability in vitro and bio-distribution in normal mice of 188Re-TTHMP were investigated. The labelling efficiency of 188Re was more than 95% on the conditions of SnCl2 of more than 0.5mg, TTHMP of more than 25 mg and at the pH value 1.5 to 3.5.188Re-TTHMP was stable in vitro with radiochemical purity of more than 92% in 4d. Bio-distribution experiment indicated that 188Re-TTHMP was principally incepted by bone of mice and the radioactivity got its peak value, (19.81±3.83)×10-2g-1, at 1 h post-injection.However, the retention of 188Re-TTHMP at bone was un-satisfied in that the bone uptake reduced to (6.23±1.52)×10-2g-1 at 48 h post-injection.

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Available abstract

TTHMP (triethylenetetraaminehexamethylenephosphonic acid) was synthesized and labeled with 188Re. Also, the stability in vitro and bio-distribution in normal mice of 188Re-TTHMP were investigated. The labelling efficiency of 188Re was more than 95% on the conditions of SnCl2 of more than 0.5mg, TTHMP of more than 25 mg and at the pH value 1.5 to 3.5.188Re-TTHMP was stable in vitro with radiochemical purity of more than 92% in 4d. Bio-distribution experiment indicated that 188Re-TTHMP was principally incepted by bone of mice and the radioactivity got its peak value, (19.81±3.83)×10-2g-1, at 1 h post-injection.However, the retention of 188Re-TTHMP at bone was un-satisfied in that the bone uptake reduced to (6.23±1.52)×10-2g-1 at 48 h post-injection.

Key concepts: Chemistry, Radiochemistry, Labelling, In vitro, Distribution (mathematics), Chromatography, Biochemistry, Mathematics

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