Effects of the dose-increasing and the priming principle on the onset time of cisatracurium.

Objective To study the effects of the dose-increasing and the priming principle on the onset time of cisatracurium.Methods Sixty patients ASAⅠ～Ⅱ,aged 30～55 years,scheduled for elective gynecologic surgery were randomly allocated to three groups with 20 cases each.Group A received cisatracurium 0.15mg/kg(3ED95) only as the control.Group B received cisatracurium 0.20mg/kg(4ED95).Group C received cisatracurium 0.03mg/kg four minutes before induction and then cisatracurium 0.12mg/kg.Neuromuscular block was monitored by a TOF Watch SX accelerograph.The onset time was recorded.Results The onset times for group A,B and C were(285.1±41.6),(143.4±28.1)and(189.2±36.2)seconds respectively.The onset time was shorter in groups of B and C than that in group A(P0.05),which was not significantly different among groups of B and C(P0.05).Conclusion Both the dose-increasing and the priming principle can decrease the onset time of cisatracurium.There are no significant differences between the effect of the dose-increasing principle and that of the priming principle.