Bioinformation of The 5′-flanking region of BCMA gene

Objective To obtain regulation information of BCMA gene,bioinformatics analyse the BCMA gene proximal 5′-flanking region.MethodsThe BCMA and 5′-flanking region were obtain from Genebank,the transcriptional factor regulation information was analysed by Tansfac 6.0 software.ResultsThe 5′-flanking region of BCMA gene was TATA-less and GAAT-less,but contain several conservative binding sites for transcription factors,such as GATA-1,Oct1.It also contains two potential binding sites for Blimp-1.ConclusionBCMA may be important in the proliferation and differentiation of B cells,transcription factor Blimp-1 may regulate the expression of BCMA gene.