2008•Chinese Journal of MisdiagnosticsRequires access

Expression and Biological Significance of Survivin in Laryngeal Squamous Cell Carcinoma

Guan Ying

Abstract

Objective:To investigate the expression of survivin and its biological significance in laryngeal squamous cell carcinomas(LSCC).Methods:The expression of survivin in 47 cases of tumour tissues、adjacent and normal tissues was detected using in situ hybridization.Results:Percentage of survivin expression was 59.6%(28/47)、25.5%(12/47)in tumour tissues and adjacent tissues respectively.In contrast,normal laryngeal tissues did not express survivin.Over expression of survivin was strongly associated with tumour grade 、TNM stage and cervical nodal metastasis.Conclusion:Survivin may be identified as a new therapeutic target.The upregulation of the expression of Survivin predicts more invasion and poor prognosis.

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Key concepts: Survivin, Medicine, Laryngeal Neoplasm, Stage (stratigraphy), Downregulation and upregulation, Pathology, Cancer research, Metastasis