Distribution and drug resistance of pathogenic bacteria from bile of patients with biliary tract infections in 5 years

OBJECTIVE To investigate the distribution of pathogenic bacteria in biliary tract infection during 2005 to 2009 and analyze the change of their drug resistance.METHODS 391 bile specimens collected for the past five years were cultured,and the bacterial identification and drug sensitivity test were performed.RESULTS A total of 265 stains were isolated and the positive rate was 55.0% including 182 Gram-negative stains,71 Gram-positive stains and 12 fungal strains.The most common pathogenic bacteria were Escherichia coli,Enterococcus faecium,Klebsiella,Enterococcus faecalis,Enterobacter and Pseudomonas aeruginosa.The results of drug resistance showed that the resistant rates of Gram-negative strains to amikacin,imipenem and penicillin/tazobactam were lower than 30.0%.The resistant rate of Gram-positive strains to vancomycin was the lowest.The drug sensitivity of fungal strains was good.CONCLUSION The varieties of pathogenic bacteria in biliary tract infection are increasing,but Gram-negative strains remain the most common bacteria.The composition ratio of Enterococcus is rising.Amikacin or penicillin/tazobactam and vancomycin may be the ideal drugs for experiential therapy.