Chorionic Villus Cell Culture and Analysis on Chromosomal Karyotype in Early Spontaneous Abortion

Objective To study the cause of early spontaneous abortion and the value of chromosomal karyotype analysis of the chorionic villus samples.Methods The chorionic villus specimens that were obtained through 60 cases of early spontaneous abortion were cultured for karyotype analysis.Results Of the 60 cases,chorionic villus was successfully cultured in 56 cases(93.3%),and abnormal embryo karyotypes were identified in 32 cases(57.1%).16 cases were antosomal triploid,6 case were multiplod,6 cases were mosaic,2 cases were sexual chromosome abnormalitie,and 2 cases were structural aberrations;normal karyotypes were identified in 24 cases(42.9%),5 cases were males and 19 cases were females.Conclusion Embryo chromosomal abnormality is a major cause of early spontaneous abortion,and karyotype analysis of the villus helps identify the causes of abortion and ensure the success of the next pregnancy.