Comparison of FLAG regimen with CAG regimen for refractory or relapsed acute myeloid leukemia

Objective:To investigate the efficacy and safety of FLAG and CAG regimen for refractory or released acute myeloid leukemia(AML).Methods: Seventy-four patients with refractory or released AML in our hospital were divided into FLAG group and CAG group.The efficacy and toxicities were analyzed and compared between the two groups.Results: The complete remission rate(CR) was 61.5% and the overall response(OR) rate was 76.9% in FLAG group.The CR rate was 35.4% and the OR rate was 50% in CAG group.For the patients with primary refractory AML or relapsed AML or refractory or relapsed AML of M1,M2,M5 subtype or those converted from myelodysplastic syndrome(MDS),the rate of CR and OR in FLAG group was higher than that in CAG group.The main toxicities of these two groups were myelosuppression.Conclusion: FLAG regimen and CAG regimen are both effective for refractory or relapsed AML,but the rate of CR and OR in FLAG group was higher,and the adverse effects from FLAG regimen were well tolerated by patients,so the FLAG regimen can be widely used further.