2008•Zhejiang Medical JournalRequires access

Association of single nucleotide polymorphisms of DNA repair gene XRCC3-241 with non-small cell lung cancer

Dan Su

Abstract

Objective To investigate the association of single nucleotide polymorphism(SNP) of XRCC3-241 gene with the development of non-small cell lung cancer(NSCLC).Methods XRCC3-241 genotype was determined by Taqman SNP genotyping assays in 103 patients with non-small cell lung cancer and 139 matched controls recruited by matching on living area,sex and age.Results In NSCLC patients the frequency of genotype C/C and C/T was 84.9%(118/139) and 15.1%(21/139),respectively.In healthy controls the frequency of genotype C/C and C/T were 88.3%(91/103) and 11.6%(12/103),respectively.The risk of genotype T/C for NSCLC was 1.004 over genotype C/C.(P0.05).Conclusion The XRCC3-241 SNP was not associated with the non-small cell lung cancer development.

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Key concepts: XRCC3, Single-nucleotide polymorphism, Genotype, Lung cancer, SNP, Genotyping, Medicine, SNP genotyping