Effects of different dose aprotinin on cardiopulmonary bypass induced inflammation and myocardial injury

Objective To compare the effects of different dose aprotinin on cardiopulmonary bypass induced inflammation and myocardial injury Methods Eighteen adult patients undergoing cardiopulmonary bypass (CPB) were divided into three groups (n=6): control,low dose aprotinin and full dose aprotinin Plasma levels of tumor necrosis factor α(TNFα), interleukin 6(IL 6), interleukin 10(IL 10), intercellular adhesion molecule 1(ICAM 1), troponin T(TnT) and neutrophil integrin cluster of differentiation 11b(CD11b) were measured at following points: before CPB(T1);1 h of CPB (T2) ;30 min after weaning from CPB (T3); 4 h after weaning from CPB (T4) ; and 24 h after weaning from CPB(T5) Results TNFα: the values in two aprotinin using groups were lower than the control levels at T2, T3 and T4 , furthermore, in full dose group was lower than in low dose group at T4 , and lower than two other groups at T5 (P0 05) IL 6: the values in full dose group were lower than those in two other groups after weaning from CPB (P0 05) CD11b: the values in two aprotinin using groups were lower than those in control group (P0 05) ICAM 1: the values in two aprotinin using groups were lower than the control levels at T3 and T4 (P0 05) IL 10: the values in full dose group were higher than those in control group at T3 (P0 05) TnT: the values in low dose group were lower than control values at T4 and T5, whereas in full dose group were lower than the values in control group following CPB and in low dose group at T4 and T5 (P0 05) Conclusions Full dose aprotinin is more effective to reduce cardiopulmonary bypass induced inflammation and myocardial injury than low dose aprotinin