EFFECTS OF METOPROLOV WITH DIGOXIN ON CHRONIC HEART FAILURE(CHF) PATIENTS WITH CHRONIC AT-RIAL FIBRILLATION(AF)

Objective To investigate the effects of metoprolol with digoxin on chronic heart failure(CHF) patients with chronic at-rial fibrillation(AF).Methods One hundred and six CHF with AF patients were divided into the metoprolol treatment group(52cases)and the control group(54cases) randomly. The general therapy included digoxin,diuretics,angiotensin converting enzyme inhibitors(ACEI)and anticoagulants. The short-term effects in 1 month and the rehospitalization rate and the mortality rate within 1 years were compared in two groups. Results The ventricular rate at rest(HR) decreased obviously(p0.01) and the distance of 6 minute walk(S) and the NYHA heart function classes and score of quality of live(QOL)improved obviously(p0.05)and left ventricular ejection fraction(LVEF) increased obviously(p0.05)in two groups 1 month after admission. But the diversity of ventricular rate before and after walk(HD)was decreased more in metoprolol group than that in control group(p0.05).The rehospitalization rate was 19.2% in the metoprolol group and 42.6% in control group(p0.05)because of deterioration in heart function within 1 years. The mortality rate was 11.5% in the metoprolol group and 20.4% in control group(p0.05)for a 1- year follow-up period.After 1 years,S,the NYHA heart function classes, score of QOL,LVEF,the left ventricular end systolic volume(LVESV) and the left ventricular end diastolic volume(LVEDV) were deteriorated in control group than that in metoprolol guoup(p0.05).Conclusion Based on the medication of diuretics,ACEI and anticoagulants,both digoxin with metoprol-ol and without metoprolol therapy can improve the short-term effects on CHF with AF patients,but the long-term prognosis of digoxin with metoprolol therapy in CHF with AF patients is better than that of digoxin without metoprolol therapy.