Comparison of TCT,Colposcopically Directed Biopsy and Loop Electrosurgical Excision Procedure in Diagnosis of Cervical Intraepithelial Neoplasia

Objective:To evaluate the significance of the check of TCT,colposcopically directed biopsy and cervical loop electrosurgical excision procedure(LEEP) in diagnosis of cervical intraepithelial neoplasia(CIN),and to compare the differences of the three kinds of methods in diagnosing CIN.Methods:LEEP was performed on 324 patients who diagnosed as CIN by TCT plus colposcopically directed biopsy.Results of diagnosing CIN by TCT,colposcopically directed biopsy and LEEP was evaluated and compared.Results:The consistence rate of the diagnosis by TCT and that by colposcopically directed biopsy was 65.1%.The diagnosis of patients by TCT was consistent with that by LEEP as confirmed by pathologic diagnosis with a consistence rate of 69.4%,the over diagnosis rate was 11.4% and the underdiagnosis rate was 18.5%.The consistence rate of the diagnosis by colpcecepically directed biopsy and that by LEEP was 68.2%,the over diagnosis rate 21.9% and the underdiagnosis rate 9.3%.The difference between the diagnosis by colposcopically directed biopsy and that by LEEP was statistically significant(P0.01).Conclusions:TCT is an effective assisting method for diagnosing CIN.The accuracy of diagnosing CIN with colposcopically directed biopsy is still unsatisfied.Cervical conization by LEEP can not be instead by colpescopically directed biopsy.It is suggested that LEEP could be a better choice for the first treatment for patients with diagnosis of CIN by TCT.