2003•PubMedRequires access
Effect of micronized fenofibrate on vascular endothelial function in patients with hypertriglyceridemia.
Yun Huang, Guizhu Dai, Zongchen Feng, Chengfa Lu, Bei Cheng, Qiufen Wang, Fuding Nie, Jingdong Li
Open publisher page 4 citations
Abstract
OBJECTIVE: To investigate the effect of micronized fenofibrate on vascular endothelial function in patients with hypertriglyceridemia. METHODS: Using high-resolution ultrasound, we measured flow- and nitroglycerin-induced dilatation of the brachial artery in 30 patients with hypertriglyceridemia before and after treatment with micronized fenofibrate at a dose of 200 mg once daily for 4 weeks. Simultaneously, both serum lipid and plasma endothelin (ET) levels were determined. RESULTS: After micronized fenofibrate therapy, serum triglyceride (TG) levels decreased significantly (P < 0.05). Plasma ET levels also decreased markedly [(82.66 +/- 15.46) microg/L vs. (106.22 +/- 19.16) microg/L, P < 0.001]. Flow-induced vasodilatation was much improved (11.0% +/- 9.0% vs 2.7% +/- 2.0%, P < 0.01). However, no significant changes in vasodilatation occurred in response to nitroglycerin (16.2% +/- 6.0% vs 15.0% +/- 5.0%, P > 0.05) in patients with hypertriglyceridemia. CONCLUSIONS: Micronized fenofibrate can improve impaired endothelium-dependent vasodilatation in patients with hypertriglyceridemia. Improving endothelial function may also be the mechanism responsible for the beneficial effects of micronized fenofibrate.