88 Strains of Acinetobacter Baumannii Resistance Status in Intensive Care Unit in A Hospital between 2011- 2012

Objective To analyze the resistance status of 88 strains of acinetobacter baumannii,so as to provide basis for the clinical control and treatment of acinetobacter baumannii. Methods 88 strains of acinetobacter baumannii were separated from sputum,lung lavage fluid,specimens of secretions,cerebrospinal fluid,purulent fluid of patients in intensive care unit from June 2011 to June 2012. VITEK-2 system was used to identify the bacteria. Drug sensitive test was conducted by MIC and K-B agar diffusion method. Acinetobacter baumannii resistance was analyzed by WHONET 5. 4 analysis software. Results Acinetobacter baumannii resistance situation is grim,the separating and resistant rate were increasing year by year,and multiple resistance and the resistance ratio increased significantly. Resistance to 7 clinical common antibiotic was tested in 88 strain of acinetobacter baumannii,the antibiotic resistance rate of cefepime,imipenem,piperacillin / tazobactam,levofloxacin,meropenem,cefoperazone / sulbactam,and amikacin were 81. 8%,79. 5%,77. 3%,71. 6%,70. 5%,53. 4%,and 11. 4%,respectively. The resistance rate to amikacin was the lowest in the data. Conclusion In view of the acinetobacter baumannii tested from intensive care unit,cefoperazone sulbactam and amikacin have higher in vitro sensitivity. In the empirical treatment of common acinetobacter baumannii,cefoperazone sulbactam is the priority choice. For the empirical treatment of drug-resistant acinetobacter baumannii,cefoperazone sulbactam combined with amikacin is recommended.