Effect of autogenous lung as oxygenator in cardiopulmonary bypass on lung protection at cardiac surgery

Objective To investigate the protection for lung function by autogenous oxgenator in cardiopulmonary bypass operation.Methods Ten piglets were randomly divided into two groups with five each.The experimental group underwent biventricular bypass with autologous lung perfusion,while control group underwent conventional cardiopulmonary bypass with artificial oxygenator.The bypass time and aortic cross clamping time were 120 min and 60 min respectively for each animal.The lung static compliance(Cstat),TNF-α,IL-6,and IL-8 were measured.Histological and ultrastructure changes of the lung were also observed after bypass.Results After cardiopulmonary bypass,the content of TNF-α,IL-6,and IL-8 increased for both groups,and the changes of experimental group were much less than those of control group(P0.05).Milder pathophysiological changes in experimental group were also demonstrated.Conclusion Autologous lung can tolerate nonpulsatile perfusion.It can be used as oxygenator in cardiopulmonary bypass operation.The autogenous oxygenator cardiopulmonary bypass technique can provide satisfactory oxygenation and even better lung function.