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2003•Zhonghua putong waike zazhiRequires access

Protective effect of hyperbaric oxygen on liver ischemic reperfusion injury in rabbits

Hong Xia

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Abstract

Objective To determine the protective effect of hyperbaric oxygen(HBO) on the liver ischemic reperfusion (I/R) injury and when the treatment should be used.Methods The rabbit hepatic inflow was occluded for 20 min,and then the occlusion was released for reperfusion. The rabbits were divided into a control group and different time(immediate,24h,72h after the 1/R injury induced) HBO therapy groups. After the operation,the waking, ALT, SOD and MDA of the rabbits were observed regularly. The hepatic tissue was observed with electronic microscope on the 11th day after the operation. Results The ALT in the immediate HBO therapy group recovered significantly faster than the control group(P0.05). The SOD level in the HBO group was higher than that in the control group(P0.05). Campared with that of the control group,the MDA level in all HBO therapy groups showed no significant difference(P0.05). The numbers of apoptosis in the immediate group, 24h group, 72h group and the control group were occasionally seen/film, 2/film, 5/film and 10/film,respectively. The lightest edema of cells was seen in the immediate group and most serious in the control group. Conclusions Hyperbaric oxygen therapy has good protective effect on liver ischemic reperfusion injury,and the earlier the HBO is used, the better the protective effect.

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What this paper is about

Objective To determine the protective effect of hyperbaric oxygen(HBO) on the liver ischemic reperfusion (I/R) injury and when the treatment should be used.Methods The rabbit hepatic inflow was occluded for 20 min,and then the occlusion was released for reperfusion. The rabbits were divided into a control group and different time(immediate,24h,72h after the 1/R injury induced) HBO therapy groups. After the operation,the waking, ALT, SOD and MDA of the rabbits were observed regularly. The hepatic tissue was observed with electronic microscope on the 11th day after the operation. Results The ALT in the immediate HBO therapy group recovered significantly faster than the control group(P0.05). The SOD level in the HBO group was higher than that in the control group(P0.05). Campared with that of the control group,the MDA level in all HBO therapy groups showed no significant difference(P0.05). The numbers of apoptosis in the immediate group, 24h group, 72h group and the control group were occasionally seen/film, 2/film, 5/film and 10/film,respectively. The lightest edema of cells was seen in the immediate group and most serious in the control group. Conclusions Hyperbaric oxygen therapy has good protective effect on liver ischemic reperfusion injury,and the earlier the HBO is used, the better the protective effect.

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Available abstract

Objective To determine the protective effect of hyperbaric oxygen(HBO) on the liver ischemic reperfusion (I/R) injury and when the treatment should be used.Methods The rabbit hepatic inflow was occluded for 20 min,and then the occlusion was released for reperfusion. The rabbits were divided into a control group and different time(immediate,24h,72h after the 1/R injury induced) HBO therapy groups. After the operation,the waking, ALT, SOD and MDA of the rabbits were observed regularly. The hepatic tissue was observed with electronic microscope on the 11th day after the operation. Results The ALT in the immediate HBO therapy group recovered significantly faster than the control group(P0.05). The SOD level in the HBO group was higher than that in the control group(P0.05). Campared with that of the control group,the MDA level in all HBO therapy groups showed no significant difference(P0.05). The numbers of apoptosis in the immediate group, 24h group, 72h group and the control group were occasionally seen/film, 2/film, 5/film and 10/film,respectively. The lightest edema of cells was seen in the immediate group and most serious in the control group. Conclusions Hyperbaric oxygen therapy has good protective effect on liver ischemic reperfusion injury,and the earlier the HBO is used, the better the protective effect.

Key concepts: Medicine, Hyperbaric oxygen, Anesthesia, Reperfusion injury, Edema, Ischemic reperfusion injury, Occlusion, Liver injury

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