Study on Toxicokinetics of Fenvalerate before and after Mixed with Phoxim

ObjectiveTo explore toxicokinetics of fenvalerate a nd the mixture of fenvalerate with phoxim.MethodsIsotope tracing technique was used to study the organ distribution of fenvalerate via two different exposure routes,tail intravenous injection and intraperitoneal administration.ResultsThe concentration of 14C\|fenvelara te residues was highest in lung after intravenous injection,which is 5.3 times of that in liver,and 16 h after that,it dropped to the concentration close to that in liver.As to the exposure by intraperitoneal injection,however,the highest concentration was found in liver,followed by the spleen and lung.Toxicokinetics parameters of single fenvalerate were calculated using residual method and compared with those of the mixed group.Both of these two toxicokinetics process fit two-compartment model.The elimination rate constant in the mixed group(0.021/min)was smaller than that in single fenvalerate group(0.036/min).Compared with single fenvalerate group,both half-time elimination and area under dpm-time curve(AUC)of 14C were significantly greater in the mixed group.ConclusionsWhen mixed with phoxim,fenvalerate elimination from the body got slower.Lung and liver may play an important role in its metabolism process.