Effects of large dosage atorvastatin on serum metalloproteinases in patients with acute coronary syndrom

Objective:To evaluated the effect of different dosage atorvastatin on serom metalloproteinases(MMP),C-reactive protein(CRP) and lipids in patiente with acute coronary syndrom(ACS) as well as its safty.Methods:46 patients with ACS were randomized to receive atorvastatin(20 mg/d,goup 1) or(40-60 mg/d,group 2) after admition.Serom lipids,CRP and MMP were assessed at baseline,1week and 4 weeks after treatment.Results:1.Compared to baseline,the levels of total cholesterol(TC),LDL-C were significantly reduced after 1 week(P0.05) and 4 weeks(P0.01) in group 2.2.MMP-2,MMP-9 and CRP significantly decreased at 1 week(P0.05)and 4 weeks(P0.01) compared to baseline in two group,But compared to that of group 1,there is more obviously decrease in group 2.3.AST,renal function and creatine kinase remained unchanged after therapy.Conclusion:Large dosage atorvastatin(40-60mg) therapy early is superior to atorvastatin(20mg) in decreasd serom lipids,anti-inflammation and stablised lipide lesion.